| 1718 - | Certification of the oldest beer factory in Romania; |
| 1718 - | opening of the first elementary school in the Citadel, the first one in Romania; |
| 1728 - | beginning of sewerage works on the Bega river, the first navigable channel in Romania; |
| 1745 - | building of the town hospital, the first one in Romania (24 years before Vienna and 34 years before Budapest); |
| 1760 - | the first town in the Monarchy with lamp-lit streets; |
| 1771 - | issuing of the first newspaper in Romania and at the same time the issuing of the first German language paper in the south-eastern Europe: "Temeswarer Nachrichten" ("Timisoara News"); |
| 1815 - | Josef Klapka's library, the first public lending library in the Habsburg Empire, in the Hungarian Kingdom and the Romanian territories; |
| 1819 - | for the fist time in Central Europe, the anti-smallpox vaccine is administered; |
| 1823 - | in Timisoara, Bolyai Janos announces the discovery of the first Non-Euclidian geometry in the world; |
| 1847 - | in the beer brewery yard, the first concert of Johann Strauss, the son, outside Vienna takes place; |
| 1855 - | the first town in the Habsburg Monarchy to have gas-lit streets; |
| 1884 - | the first town in Europe to have electrically lit streets, with 731 lamps; |
| 1886 - | the first emergency service unit in Hungary and Romania; |
| 1895 - | the first paved street in Romania; |
| 1899 - | the first electric tram in Romania; |
| 1938 - | a world premiere, the first welding machine for railway and tram rails, an invention of professor Corneliu Miclosi; |
| 1953 - | the only European town to have three state theatres in three languages: Romanian, Hungarian and German; |
| 1969 - | Professor Ghermanescu publishes the first encyclopedic treatise on functional equations in the world; |
| 1989 - | first free town in Romania; |
| 1992 - | the first laparoscopic surgical operations in gynecology and the first plastic breast surgeries with prostheses (in collaboration with the Gynecology Clinics from Heidelberg); |
| 1993 - | the first complete laparoscopic hysterectomy (in collaboration with the Clinics from Kiel); |
| 1995 - | the first vitro fertilization and the first human embryo transfer in Romania; founding the first Laparoscopy, Laparoscopic Surgery and Vitro Fertilization Centre, Timisoara; |
| 1996 - | birth of the first vitro conceived child in Romania and the first embryo transfer to the child bearing mother, performance of professor Ioan Munteanu’s team; |
| 2000 - | the first town in Romania to have an economic-social development strategy, created by the Timisoara Town Hall; |
| 2001 - | the first info-shops network in Romania, courtesy of the Timisoara Town Hall; |
| 2001 - | the first heart laser surgery in Romania; |
| 2001 - | the first social project on civic involvement trying to solve social issues - The Faenza House, pilotcenter for children with the autistic syndrome, created in partnership by the Timisoara Town Hall and the Faenza Town Hall; |
| 2001 - | the organization of the first public hearing in Romania, by the Timisoara Local Council; |
| 2002 - | national premiere in implementing an internet based system for the payment of taxes and fees. |
| 2002 - | the first newspaper issued by a town hall and distributed to the population free - "The Town Hall Gazette"; |
| 2003 - | introducing a new traffic light system ("the green wave"); |
| 2003 - | set up of the first sculpture park in Romania, situated at the crossroads of the Mures and the Calea Martirilor streets; |
| 2003 - | the first transplant of hematopatic stem cells, aiming at the recovery of the heart muscle on a patient suffering from a myocardium infarct (the first operation of this kind in Eastern Europe, performed by the team of Professor Doctor Stefan I. Dragulescu); |
| 2003 - | the first Call Center (969) service of a local public administration in Romania; |
| 2004 - | national premiere in broadcasting the meetings of the Local Council live via Internet (www.primariatm.ro); |
| 2005 - | public transportation service with buses especially made for disabled persons; |
| 2006 - | phone-alarm system, automated system for home monitoring of aged persons |
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